A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present

A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present

Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helpe...

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Bibliographic Details
Main Authors: Sheng, Jianpeng, Chen, Qi, Soncin, Irene, Ng, See Liang, Karjalainen, Klaus, Ruedl, Christiane
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
Subjects:
Antigen-presenting Cell
Dendritic Cells
Online Access:https://hdl.handle.net/10356/88625
http://hdl.handle.net/10220/44681
https://doi.org/10.21979/N9/H3VUH9
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Institution: Nanyang Technological University
Language: English
Description
Summary:Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-DC-derived conventional DCs (cDCs), including cDC1s and cDC2s, from monocyte-derived Mϕs. Here, we further refine DC/Mϕ cell classification and report that classically defined cDC2s contain a discrete population of monocyte-derived migratory antigen-presenting cells with Mϕ phenotype but functional DC features, including cross-presentation.

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