A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present

A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present

Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helpe...

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Main Authors: Sheng, Jianpeng, Chen, Qi, Soncin, Irene, Ng, See Liang, Karjalainen, Klaus, Ruedl, Christiane
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
Subjects:
Antigen-presenting Cell
Dendritic Cells
Online Access:https://hdl.handle.net/10356/88625
http://hdl.handle.net/10220/44681
https://doi.org/10.21979/N9/H3VUH9
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-886252023-02-28T17:03:23Z A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present Sheng, Jianpeng Chen, Qi Soncin, Irene Ng, See Liang Karjalainen, Klaus Ruedl, Christiane School of Biological Sciences Antigen-presenting Cell Dendritic Cells Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-DC-derived conventional DCs (cDCs), including cDC1s and cDC2s, from monocyte-derived Mϕs. Here, we further refine DC/Mϕ cell classification and report that classically defined cDC2s contain a discrete population of monocyte-derived migratory antigen-presenting cells with Mϕ phenotype but functional DC features, including cross-presentation. MOE (Min. of Education, S’pore) Published version 2018-04-12T08:21:52Z 2019-12-06T17:07:32Z 2018-04-12T08:21:52Z 2019-12-06T17:07:32Z 2017 Journal Article Sheng, J., Chen, Q., Soncin, I., Ng, S. L., Karjalainen, K., & Ruedl, C. (2017). A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present. Cell Reports, 21(5), 1203-1214. 2211-1247 https://hdl.handle.net/10356/88625 http://hdl.handle.net/10220/44681 10.1016/j.celrep.2017.10.024 en Cell Reports https://doi.org/10.21979/N9/H3VUH9 © 2017 The Author(s). This paper was published in Cell Reports and is made available as an electronic reprint (preprint) with permission of The Author(s). The published version is available at: [http://dx.doi.org/10.1016/j.celrep.2017.10.024]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 12 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Antigen-presenting Cell
Dendritic Cells
spellingShingle Antigen-presenting Cell
Dendritic Cells
Sheng, Jianpeng
Chen, Qi
Soncin, Irene
Ng, See Liang
Karjalainen, Klaus
Ruedl, Christiane
A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present
description Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-DC-derived conventional DCs (cDCs), including cDC1s and cDC2s, from monocyte-derived Mϕs. Here, we further refine DC/Mϕ cell classification and report that classically defined cDC2s contain a discrete population of monocyte-derived migratory antigen-presenting cells with Mϕ phenotype but functional DC features, including cross-presentation.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Sheng, Jianpeng
Chen, Qi
Soncin, Irene
Ng, See Liang
Karjalainen, Klaus
Ruedl, Christiane
format Article
author Sheng, Jianpeng
Chen, Qi
Soncin, Irene
Ng, See Liang
Karjalainen, Klaus
Ruedl, Christiane
author_sort Sheng, Jianpeng
title A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present
title_short A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present
title_full A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present
title_fullStr A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present
title_full_unstemmed A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present
title_sort discrete subset of monocyte-derived cells among typical conventional type 2 dendritic cells can efficiently cross-present
publishDate 2018
url https://hdl.handle.net/10356/88625
http://hdl.handle.net/10220/44681
https://doi.org/10.21979/N9/H3VUH9
_version_ 1759852957208150016

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