A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present

• المؤلفون الرئيسيون: Sheng, Jianpeng, Chen, Qi, Soncin, Irene, Ng, See Liang, Karjalainen, Klaus, Ruedl, Christiane
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Antigen-presenting Cell; Dendritic Cells
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/88625; http://hdl.handle.net/10220/44681; https://doi.org/10.21979/N9/H3VUH9
• المؤسسة: Nanyang Technological University

Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-DC-derived conventional DCs (cDCs), including cDC1s and cDC2s, from monocyte-derived Mϕs. Here, we further refine DC/Mϕ cell classification and report that classically defined cDC2s contain a discrete population of monocyte-derived migratory antigen-presenting cells with Mϕ phenotype but functional DC features, including cross-presentation.