Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype–anti-idiotype Fab complex

• المؤلفون الرئيسيون: Wong, Yee Hwa, Goh, Boon Chong, Lim, She Yah, Teo, En Wei, Lim, Angeline P. C., Dedon, Pete C., Hanson, Brendon J., MacAry, Paul A., Lescar, Julien
• مؤلفون آخرون: Jung, Jae U.
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: DRNTU::Science::Biological sciences; Dengue Virus; Idiotypic Antibody
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/88847; http://hdl.handle.net/10220/45924

A detailed understanding of the fine specificity of serotype-specific human antibodies is vital for the development and evaluation of new vaccines for pathogenic flaviviruses such as dengue virus (DENV) and Zika virus. In this study, we thoroughly characterize the structural footprint of an anti-idi...