Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype–anti-idiotype Fab complex

• Main Authors: Wong, Yee Hwa, Goh, Boon Chong, Lim, She Yah, Teo, En Wei, Lim, Angeline P. C., Dedon, Pete C., Hanson, Brendon J., MacAry, Paul A., Lescar, Julien
• 其他作者: Jung, Jae U.
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: DRNTU::Science::Biological sciences; Dengue Virus; Idiotypic Antibody
• 在線閱讀: https://hdl.handle.net/10356/88847; http://hdl.handle.net/10220/45924

A detailed understanding of the fine specificity of serotype-specific human antibodies is vital for the development and evaluation of new vaccines for pathogenic flaviviruses such as dengue virus (DENV) and Zika virus. In this study, we thoroughly characterize the structural footprint of an anti-idi...