Early developmental perturbations in a human stem cell model of MODY5/HNF1B pancreatic hypoplasia

• Main Authors: Teo, Adrian Kee Keong, Lau, Hwee Hui, Valdez, Ivan Achel, Dirice, Ercument, Tjora, Erling, Raeder, Helge, Kulkarni, Rohit N.
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: DRNTU::Science::Medicine; Stem Cell; Molecular Mechanisms
• 在線閱讀: https://hdl.handle.net/10356/88907; http://hdl.handle.net/10220/46988
• 機構: Nanyang Technological University

Patients with an HNF1BS148L/+ mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully recapitulate MODY5. Here, we differentiated MODY5 human-induced pluripotent stem cell...