SynLethDB : synthetic lethality database toward discovery of selective and sensitive anticancer drug targets

• Main Authors: Guo, Jing, Liu, Hui, Zheng, Jie
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Database Issue; DRNTU::Engineering::Computer science and engineering; Synthetic Lethality (SL)
• Online Access: https://hdl.handle.net/10356/88975; http://hdl.handle.net/10220/46043; https://doi.org/10.21979/N9/CVEVDZ
• Institution: Nanyang Technological University

Synthetic lethality (SL) is a type of genetic interaction between two genes such that simultaneous perturbations of the two genes result in cell death or a dramatic decrease of cell viability, while a perturbation of either gene alone is not lethal. SL reflects the biologically endogenous difference...