Nickel-Catalyzed Asymmetric Reductive Heck Cyclization of Aryl Halides to Afford Indolines

• Main Authors: Qin, Xurong, Lee, Marcus Wen Yao, Zhou, Steve Jianrong
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Asymmetric Catalysis; Cyclization
• 在線閱讀: https://hdl.handle.net/10356/89028; http://hdl.handle.net/10220/44927

A nickel‐catalyzed asymmetric reductive Heck reaction of aryl chlorides has been developed that affords substituted indolines with high enantioselectivity. Manganese powder is used as the terminal reductant with water as a proton source. Mechanistically, it is distinct from the palladium‐catalyzed p...