Nickel-Catalyzed Asymmetric Reductive Heck Cyclization of Aryl Halides to Afford Indolines

• المؤلفون الرئيسيون: Qin, Xurong, Lee, Marcus Wen Yao, Zhou, Steve Jianrong
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Asymmetric Catalysis; Cyclization
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/89028; http://hdl.handle.net/10220/44927
• المؤسسة: Nanyang Technological University

A nickel‐catalyzed asymmetric reductive Heck reaction of aryl chlorides has been developed that affords substituted indolines with high enantioselectivity. Manganese powder is used as the terminal reductant with water as a proton source. Mechanistically, it is distinct from the palladium‐catalyzed p...