How RNA catalyzes cyclization

The long-awaited crystal structure of the Varkud satellite (VS) ribozyme dimer provides atomic-level insights into how the VS ribozyme folds and catalyzes RNA circularization during rolling circle replication, as well as revealing convergent evolution used by RNAs to catalyze an SN2 reaction.

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Main Authors: Zhong, Zhensheng, Chen, Gang
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2018
Subjects:
RNA
Online Access:https://hdl.handle.net/10356/89213
http://hdl.handle.net/10220/44839
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-892132023-02-28T19:35:51Z How RNA catalyzes cyclization Zhong, Zhensheng Chen, Gang School of Physical and Mathematical Sciences Nucleic Acids RNA The long-awaited crystal structure of the Varkud satellite (VS) ribozyme dimer provides atomic-level insights into how the VS ribozyme folds and catalyzes RNA circularization during rolling circle replication, as well as revealing convergent evolution used by RNAs to catalyze an SN2 reaction. MOE (Min. of Education, S’pore) Accepted version 2018-05-18T07:54:46Z 2019-12-06T17:20:22Z 2018-05-18T07:54:46Z 2019-12-06T17:20:22Z 2015 Journal Article Zhong, Z., & Chen, G. (2015). How RNA catalyzes cyclization. Nature Chemical Biology, 11, 830-831. 1552-4450 https://hdl.handle.net/10356/89213 http://hdl.handle.net/10220/44839 10.1038/nchembio.1928 en Nature Chemical Biology © 2015 Nature America, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Nature Chemical Biology, Nature America, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at [http://dx.doi.org/10.1038/nchembio.1928]. 5 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Nucleic Acids
RNA
spellingShingle Nucleic Acids
RNA
Zhong, Zhensheng
Chen, Gang
How RNA catalyzes cyclization
description The long-awaited crystal structure of the Varkud satellite (VS) ribozyme dimer provides atomic-level insights into how the VS ribozyme folds and catalyzes RNA circularization during rolling circle replication, as well as revealing convergent evolution used by RNAs to catalyze an SN2 reaction.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Zhong, Zhensheng
Chen, Gang
format Article
author Zhong, Zhensheng
Chen, Gang
author_sort Zhong, Zhensheng
title How RNA catalyzes cyclization
title_short How RNA catalyzes cyclization
title_full How RNA catalyzes cyclization
title_fullStr How RNA catalyzes cyclization
title_full_unstemmed How RNA catalyzes cyclization
title_sort how rna catalyzes cyclization
publishDate 2018
url https://hdl.handle.net/10356/89213
http://hdl.handle.net/10220/44839
_version_ 1759854270108139520