How RNA catalyzes cyclization

The long-awaited crystal structure of the Varkud satellite (VS) ribozyme dimer provides atomic-level insights into how the VS ribozyme folds and catalyzes RNA circularization during rolling circle replication, as well as revealing convergent evolution used by RNAs to catalyze an SN2 reaction.

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Bibliographic Details
Main Authors: Zhong, Zhensheng, Chen, Gang
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2018
Subjects:
RNA
Online Access:https://hdl.handle.net/10356/89213
http://hdl.handle.net/10220/44839
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Institution: Nanyang Technological University
Language: English