Enterococcus faecalis Modulates Immune Activation and Slows Healing During Wound Infection

• Main Authors: Chong, Kelvin Kian Long, Tay, Wei Hong, Janela, Baptiste, Yong, Adeline Mei Hui, Liew, Tze Horng, Madden, Leigh, Keogh, Damien, Barkham, Timothy Mark Sebastian, Ginhoux, Florent, Becker, David Laurence, Kline, Kimberly A.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Enterococcus Faecalis; Wound Infection
• Online Access: https://hdl.handle.net/10356/89307; http://hdl.handle.net/10220/44854
• Institution: Nanyang Technological University

Enterococcus faecalis is one of the most frequently isolated bacterial species in wounds yet little is known about its pathogenic mechanisms in this setting. Here, we used a mouse wound excisional model to characterize the infection dynamics of E faecalis and show that infected wounds result in 2 di...