Characterization of the regulation of CD46 RNA alternative splicing

• Main Authors: Tang, Sze Jing, Luo, Shufang, Ly, Phuong Thao, Goh, Eling, Roca, Xavier, Ho, Jessie Jia Xin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Alternative Splicing; Complement System; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/89443; http://hdl.handle.net/10220/46266
• Institution: Nanyang Technological University

Here we present a detailed analysis of the alternative splicing regulation of human CD46, which generates different isoforms with distinct functions. CD46 is a ubiquitous membrane protein that protects host cells from complement and plays other roles in immunity, autophagy, and cell adhesion. CD46 d...