Cat-D: a targeted sequencing method for the simultaneous detection of small DNA mutations and large DNA deletions with flexible boundaries

• Main Authors: Hong, Ru, Chandola, Udita, Zhang, Li-Feng
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Targeted DNA Sequencing Method; DNA Mutations
• Online Access: https://hdl.handle.net/10356/89522; http://hdl.handle.net/10220/44982
• Institution: Nanyang Technological University

We developed a targeted DNA sequencing method that is capable of detecting a comprehensive panel of DNA mutations including small DNA mutations and large DNA deletions with unknown/flexible boundaries. The method directly identifies the large DNA deletions (Cat-D) without relying on sequencing cover...