The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis

• Main Authors: Ingham, Philip William, Prabhakar, Shyam, Leow, Melvin K. S., Lee, Yung Seng, Ng, Kai Lyn, Leow, Shi Chi, Poschmann, Jeremie, Too, Peh Gek, Yin, Juan, Joseph, Roy, McFarlane, Craig, Dogra, Shaillay, Shabbir, Asim, Chong, Yap Seng, Gluckman, Peter D., Stünkel, Walter
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Epigenetics; Development Origins; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/89571; http://hdl.handle.net/10220/47096
• Institution: Nanyang Technological University

An association between impaired fetal growth and the postnatal development of obesity has been established. Here, by comparing adipocytes differentiated from mesenchymal stem cells (MSCs) taken from the umbilical cord and derived from normal and growth-restricted neonates, we identified the transcri...