TFPI-2 protects against gram-negative bacterial infection

• Main Authors: Ali, Mohamad N., Kasetty, Gopinath, Elvén, Malin, Alyafei, Saud, Jovic, Sandra, Egesten, Arne, Herwald, Heiko, Schmidtchen, Artur, Papareddy, Praveen
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Medicine; TFPI-2; Antimicrobial Peptide
• Online Access: https://hdl.handle.net/10356/89583; http://hdl.handle.net/10220/46296
• Institution: Nanyang Technological University

Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad ant...