Blocking sense‐strand activity improves potency, safety and specificity of anti‐hepatitis B virus short hairpin RNA

Blocking sense‐strand activity improves potency, safety and specificity of anti‐hepatitis B virus short hairpin RNA

Hepatitis B virus (HBV) is a promising target for therapies based on RNA interference (RNAi) since it replicates via RNA transcripts that are vulnerable to RNAi silencing. Clinical translation of RNAi technology, however, requires improvements in potency, specificity and safety. To this end, we syst...

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Bibliographic Details
Main Authors: Michler, Thomas, Große, Stefanie, Mockenhaupt, Stefan, Röder, Natalie, Stückler, Ferdinand, Knapp, Bettina, Ko, Chunkyu, Heikenwalder, Mathias, Protzer, Ulrike, Grimm, Dirk
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
Subjects:
Adeno-associated Virus
Hepatitis B Virus
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/89826
http://hdl.handle.net/10220/47140
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/89826
http://hdl.handle.net/10220/47140

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