Blocking sense‐strand activity improves potency, safety and specificity of anti‐hepatitis B virus short hairpin RNA

• Main Authors: Michler, Thomas, Große, Stefanie, Mockenhaupt, Stefan, Röder, Natalie, Stückler, Ferdinand, Knapp, Bettina, Ko, Chunkyu, Heikenwalder, Mathias, Protzer, Ulrike, Grimm, Dirk
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Adeno-associated Virus; Hepatitis B Virus; DRNTU::Science::Biological sciences
• 在線閱讀: https://hdl.handle.net/10356/89826; http://hdl.handle.net/10220/47140

Hepatitis B virus (HBV) is a promising target for therapies based on RNA interference (RNAi) since it replicates via RNA transcripts that are vulnerable to RNAi silencing. Clinical translation of RNAi technology, however, requires improvements in potency, specificity and safety. To this end, we syst...