Neighborhood regularized logistic matrix factorization for drug-target interaction prediction

• Main Authors: Liu, Yong, Wu, Min, Miao, Chunyan, Zhao, Peilin, Li, Xiao-Li
• Other Authors: Przytycka, Teresa M.
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Engineering::Computer science and engineering; Neighborhood Regularized Logistic Matrix Factorization; Drug-Target Interaction
• Online Access: https://hdl.handle.net/10356/89929; http://hdl.handle.net/10220/46442
• Institution: Nanyang Technological University

In pharmaceutical sciences, a crucial step of the drug discovery process is the identification of drug-target interactions. However, only a small portion of the drug-target interactions have been experimentally validated, as the experimental validation is laborious and costly. To improve the drug di...