Neighborhood regularized logistic matrix factorization for drug-target interaction prediction

• المؤلفون الرئيسيون: Liu, Yong, Wu, Min, Miao, Chunyan, Zhao, Peilin, Li, Xiao-Li
• مؤلفون آخرون: Przytycka, Teresa M.
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: DRNTU::Engineering::Computer science and engineering; Neighborhood Regularized Logistic Matrix Factorization; Drug-Target Interaction
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/89929; http://hdl.handle.net/10220/46442
• المؤسسة: Nanyang Technological University

In pharmaceutical sciences, a crucial step of the drug discovery process is the identification of drug-target interactions. However, only a small portion of the drug-target interactions have been experimentally validated, as the experimental validation is laborious and costly. To improve the drug di...