Human beta cells produce and release serotonin to inhibit glucagon secretion from alpha cells

• Main Authors: Almaça, Joana, Molina, Judith, Menegaz, Danusa, Pronin, Alexey N., Tamayo, Alejandro, Slepak, Vladlen, Berggren, Per-Olof, Caicedo, Alejandro
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Medicine; Serotonin; Beta Cell
• Online Access: https://hdl.handle.net/10356/89948; http://hdl.handle.net/10220/46464
• Institution: Nanyang Technological University

In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during metabolic challenges such as those associated with pregnancy or high-fat diet. It is still unclear whether serotonin is relevant for regular islet physiology and hormone secretion. Here, we show that human bet...