P53 maintains genomic stability by preventing interference between transcription and replication

• Main Authors: Yeo, Constance Qiao Xin, Alexander, Irina, Lin, Zhaoru, Lim, Shuhui, Aning, Obed Akwasi, Kumar, Ramesh, Sangthongpitag, Kanda, Pendharkar, Vishal, Ho, Vincent H.B., Cheok, Chit Fang
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Gyrase Inhibitor; Protein p53; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/89990; http://hdl.handle.net/10220/46473
• Institution: Nanyang Technological University

p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest, senescence, and apoptosis. We discovered a function of p53 in preventing conflicts between transcription and replication, independent of its canonical roles. p53 deficiency sensitizes cells to Topoisomerase...