P53 maintains genomic stability by preventing interference between transcription and replication

p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest, senescence, and apoptosis. We discovered a function of p53 in preventing conflicts between transcription and replication, independent of its canonical roles. p53 deficiency sensitizes cells to Topoisomerase...

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Bibliographic Details
Main Authors: Yeo, Constance Qiao Xin, Alexander, Irina, Lin, Zhaoru, Lim, Shuhui, Aning, Obed Akwasi, Kumar, Ramesh, Sangthongpitag, Kanda, Pendharkar, Vishal, Ho, Vincent H.B., Cheok, Chit Fang
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2018
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Online Access:https://hdl.handle.net/10356/89990
http://hdl.handle.net/10220/46473
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Institution: Nanyang Technological University
Language: English

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