P53 maintains genomic stability by preventing interference between transcription and replication
p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest, senescence, and apoptosis. We discovered a function of p53 in preventing conflicts between transcription and replication, independent of its canonical roles. p53 deficiency sensitizes cells to Topoisomerase...
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Main Authors: | Yeo, Constance Qiao Xin, Alexander, Irina, Lin, Zhaoru, Lim, Shuhui, Aning, Obed Akwasi, Kumar, Ramesh, Sangthongpitag, Kanda, Pendharkar, Vishal, Ho, Vincent H.B., Cheok, Chit Fang |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2018
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/89990 http://hdl.handle.net/10220/46473 |
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Institution: | Nanyang Technological University |
Language: | English |
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