Targeting nuclear receptors in cancer-associated fibroblasts as concurrent therapy to inhibit development of chemoresistant tumors

• Main Authors: Chan, Jeremy Soon Kiat, Sng, Ming Keat, Teo, Zi Qiang, Chong, Han Chung, Twang, Jing Shun, Tan, Nguan Soon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Squamous Cell Carcinoma; Cancer Microenvironment
• Online Access: https://hdl.handle.net/10356/90275; http://hdl.handle.net/10220/48495
• Institution: Nanyang Technological University

Most anticancer therapies to date focus on druggable features of tumor epithelia. Despite the increasing repertoire of treatment options, patient responses remain varied. Moreover, tumor resistance and relapse remain persistent clinical challenges. These observations imply an incomplete understandin...