Preproinsulin designer antigens excluded from endoplasmic reticulum suppressed diabetes development in nod mice by dna vaccination

• Main Authors: Stifter, Katja, Schuster, Cornelia, Krieger, Jana, Spyrantis, Andreas, Boehm, Bernhard Otto, Schirmbeck, Reinhold
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Mouse Models; Type 1 Diabetes; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/90285; http://hdl.handle.net/10220/48490
• Institution: Nanyang Technological University

DNA vaccines against autoimmune type 1 diabetes (T1D) contain a nonpredictable risk to induce autoreactive T cell responses rather than a protective immunity. Little is known if (and how) antigen expression and processing requirements favor the induction of autoreactive or protective immune response...