Cobalt-catalyzed C(sp2)–H/C(sp3)–H coupling via directed C–H activation and 1,5-hydrogen atom transfer

• Main Authors: Sun, Qiao, Yoshikai, Naohiko
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Catalyst; DRNTU::Science::Chemistry; Hydrogen Atom Transfer
• Online Access: https://hdl.handle.net/10356/90289; http://hdl.handle.net/10220/48486
• Institution: Nanyang Technological University

A cobalt-catalyzed C(sp2)–H/C(sp3)–H coupling reaction between an aryl imine and a 2-bromobenzyl-protected secondary amine is reported. Promoted by a combination of a cobalt–N-heterocyclic carbene catalyst and a Grignard reagent, the reaction allows for the introduction of α-aminoalkyl groups into t...