Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells

• Main Authors: Diao, Hua Jia, Low, Wei Ching, Milbreta, Ulla, Lu, Q. Richard, Chew, Sing Yian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: Oligodendroglial precursor cells; Remyelination
• Online Access: https://hdl.handle.net/10356/93138; http://hdl.handle.net/10220/40991
• Institution: Nanyang Technological University

Remyelination in the central nervous system (CNS) is critical in the treatment of many neural pathological conditions. Unfortunately, the ability to direct and enhance oligodendrocyte (OL) differentiation and maturation remains limited. It is known that microenvironmental signals, such as substrate...