Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB

• Main Authors: Krainer, Adrian R., Chew, Shern L., Khoo, Bernard, Roca, Xavier
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/93822; http://hdl.handle.net/10220/6875
• Institution: Nanyang Technological University

Background: Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons. APOB exists as two natural isoforms: the full-length APOB100 isoform, assembled int...