Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB

• Main Authors: Krainer, Adrian R., Chew, Shern L., Khoo, Bernard, Roca, Xavier
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2011
• 主題: DRNTU::Science::Biological sciences::Molecular biology
• 在線閱讀: https://hdl.handle.net/10356/93822; http://hdl.handle.net/10220/6875
• 機構: Nanyang Technological University

Background: Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons. APOB exists as two natural isoforms: the full-length APOB100 isoform, assembled int...