Solution structure of a pleckstrin-homology domain

• Main Authors: Hajduk, Philip J., Petros, Andrew M., Olejniczak, Edward T., Meadows, Robert P., Fesik, Stephen W., Yoon, Ho Sup
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/93937; http://hdl.handle.net/10220/7656
• Institution: Nanyang Technological University

PLECKSTRIN1, the major protein kinase C substrate of platelets, contains domains of about 100 amino acids at the amino and carboxy termini that have been found in a number of proteins, including serine/threonine kinases, GTPase-activating proteins, phospholipases and cytoskeletal proteins2–5. These...