Crystal structure of the FK506 binding domain of plasmodium falciparum FKBP35 in complex with FK506

• المؤلفون الرئيسيون: Kotaka, Masayo, Ye, Hong, Alag, Reema, Hu, Guangan, Bozdech, Zbynek, Preiser, Peter Rainer, Yoon, Ho Sup, Lescar, Julien
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2012
• الموضوعات: DRNTU::Science::Biological sciences::Microbiology::Virology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/93954; http://hdl.handle.net/10220/7482
• المؤسسة: Nanyang Technological University

The emergence of multi-drug-resistant strains of Plasmodium parasites has prompted the search for alternative therapeutic strategies for combating malaria. One possible strategy is to exploit existing drugs as lead compounds. FK506 is currently used in the clinic for preventing transplant rejection....