NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35

• Main Authors: Alag, Reema, Qureshi, Insaf A, Bharatham, Nagakumar, Shin, Joon, Yoon, Ho Sup, Lescar, Julien
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Chemistry::Analytical chemistry::Proteins
• Online Access: https://hdl.handle.net/10356/95151; http://hdl.handle.net/10220/8712
• Institution: Nanyang Technological University

The emergence of drug-resistant malaria parasites is the major threat to effective malaria control, prompting a search for novel compounds with mechanisms of action that are different from the traditionally used drugs. The immunosuppressive drug FK506 shows an antimalarial activity. The mechanism of...