NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35

• Main Authors: Alag, Reema, Qureshi, Insaf A, Bharatham, Nagakumar, Shin, Joon, Yoon, Ho Sup, Lescar, Julien
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2012
• 主題: DRNTU::Science::Chemistry::Analytical chemistry::Proteins
• 在線閱讀: https://hdl.handle.net/10356/95151; http://hdl.handle.net/10220/8712
• 機構: Nanyang Technological University

The emergence of drug-resistant malaria parasites is the major threat to effective malaria control, prompting a search for novel compounds with mechanisms of action that are different from the traditionally used drugs. The immunosuppressive drug FK506 shows an antimalarial activity. The mechanism of...