Solution structure of the antiapoptotic protein bcl-2

Solution structure of the antiapoptotic protein bcl-2

The structures of two isoforms of Bcl-2 that differ by two amino acids have been determined by NMR spectroscopy. Because wild-type Bcl-2 behaved poorly in solution, the structures were determined by using Bcl-2/Bcl-xL chimeras in which part of the putative unstructured loop of Bcl-2 was replaced wit...

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Bibliographic Details
Main Authors: Petros, Andrew M., Nettesheim, David G., Kim, Daniel H., Matayoshi, Edmund D., Fesik, Stephen W., Medek, Ales, Yoon, Ho Sup, Swift, Kerry, Oltersdorf, Tilman
Other Authors: School of Biological Sciences
Format: Conference or Workshop Item
Language:English
Published: 2012
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/94051
http://hdl.handle.net/10220/7509
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/94051
http://hdl.handle.net/10220/7509

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