Solution structure of the antiapoptotic protein bcl-2

• Main Authors: Petros, Andrew M., Nettesheim, David G., Kim, Daniel H., Matayoshi, Edmund D., Fesik, Stephen W., Medek, Ales, Yoon, Ho Sup, Swift, Kerry, Oltersdorf, Tilman
• Other Authors: School of Biological Sciences
• Format: Conference or Workshop Item
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/94051; http://hdl.handle.net/10220/7509
• Institution: Nanyang Technological University

The structures of two isoforms of Bcl-2 that differ by two amino acids have been determined by NMR spectroscopy. Because wild-type Bcl-2 behaved poorly in solution, the structures were determined by using Bcl-2/Bcl-xL chimeras in which part of the putative unstructured loop of Bcl-2 was replaced wit...