On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid

• Main Authors: Shu, Jian Jun, Lim, C. W.
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2011
• Subjects: DRNTU::Engineering::Mechanical engineering::Bio-mechatronics
• Online Access: https://hdl.handle.net/10356/94086; http://hdl.handle.net/10220/7224
• Institution: Nanyang Technological University

The paper aims at extending, utilising and generalising research in nonlinear dynamics of (i) spiral/helicoidal structures, and (ii) viscous, low speed fluid to biomechanical DNA fluidstructure interaction. Employing a nonlinear helicoidal model, the energy stored in a distorted Watson-Crick DNA model subjected to viscous, low speed organic fluid loading is formulated. Numerical solutions based on the variational principle are presented for a linearized flow field as examples. Significant dynamical responses such as deformation components and resultants are discussed. A proposal for matching of DNA sequential characteristics with respect to the nonlinear dynamical responses is outlined in order to reveal information regarding DNA sequencing by means of a fluid-structure dynamical approach.