Studies on a DNA double helicoidal structure immersed in viscous bio-fluid

• Main Authors: Shu, Jian Jun, Lim, C. W.
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Conference or Workshop Item
• Language: English
• Published: 2011
• Subjects: DRNTU::Engineering::Mechanical engineering::Bio-mechatronics
• Online Access: https://hdl.handle.net/10356/94088; http://hdl.handle.net/10220/7223; http://www.nsti.org/procs/ICCN2002/15/W63.03
• Institution: Nanyang Technological University

The paper aims at extending, utilising and generalising research in nonlinear dynamics of (i) spiral/helicoidal structures, and (ii) viscous, low speed fluid to biomechanical DNA fluid-structure interaction. Employing a nonlinear helicoidal model, the energy stored in a distorted Watson-Crick DNA model subjected to viscous, low speed organic fluid loading is examined. An efficient recursive numerical scheme based on the variational principle is presented. Significant dynamical responses such as energy distribution, bending and twisting of DNA model under organic fluid excitations are discussed. Matching of DNA sequential characteristics with respect to the nonlinear dynamical responses is outlined in order to reveal information regarding DNA sequencing by means of a fluid-structure dynamical approach.