Stimulation of transcript elongation requires both the zinc finger and RNA polymerase II binding domains of human TFIIS

• Main Authors: Agarwal, Kan, Baek, Kwanghee, Jeon, Choon Ju, Miyamoto, Kenichi, Ueno, Akemichi, Yoon, Ho Sup
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Chemistry::Biochemistry
• Online Access: https://hdl.handle.net/10356/94386; http://hdl.handle.net/10220/7480
• Institution: Nanyang Technological University

The eukaryotic transcriptional factor TFIIS enhances transcript elongation by RNA polymerase II. Here we describe two functional domains in the 280 amino acid human TFIIS protein: residues within positions 100-230 are required for binding...