The transcription factor TFIIS zinc ribbon dipeptide Asp-Glu is critical for stimulation of elongation and RNA cleavage by RNA polymerase II

• Main Authors: Jeon, Choon Ju, Yoon, Ho Sup, Agarwal, Kan
• Other Authors: School of Biological Sciences
• Format: Conference or Workshop Item
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Chemistry::Biochemistry
• Online Access: https://hdl.handle.net/10356/94050; http://hdl.handle.net/10220/7484
• Institution: Nanyang Technological University

The eukaryotic transcription factor TFIIS enhances elongation and nascent transcript cleavage activities of RNA polymerase II in a stalled elongation complex. By site-directed mutagenesis, we have demonstrated that invariant residues Asp-261 and Glu-262 of the nucleic acid-binding TFIIS Zn ribbon ar...