Labeling and tracking P2 purinergic receptors in living cells using ATP-conjugated quantum dots

Labeling and tracking P2 purinergic receptors in living cells using ATP-conjugated quantum dots

It has been increasingly recognized that adenosine-5 ′ -triphosphate (ATP) signaling through P2 purinergic receptors has a diverse infl uence on cell functions and human health. In this contribution, a simple and non-invasive method to specifi cally label P2 receptors using ATP-...

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Bibliographic Details
Main Authors: Jiang, Shan, Liu, Aiping, Duan, Hongwei, Soo, Jianchow, Chen, Peng
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2012
Subjects:
DRNTU::Engineering::Chemical engineering
Online Access:https://hdl.handle.net/10356/94388
http://hdl.handle.net/10220/7492
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Institution: Nanyang Technological University
Language: English
Description
Summary:It has been increasingly recognized that adenosine-5 ′ -triphosphate (ATP) signaling through P2 purinergic receptors has a diverse infl uence on cell functions and human health. In this contribution, a simple and non-invasive method to specifi cally label P2 receptors using ATP-conjugated quantum dots (QDs) is demonstrated. In addition, the endocytosis, vesicular traffi cking, and recycling of QD-labeled P2 receptors are studied under different physiological conditions using confocal and total internal refl ection fl uorescence microscopy.

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