Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays
Adipose tissue is a highly active endocrine organ secreting a variety of signaling molecules called adipokines. Leptin and resistin are two adipokines critically involved in metabolic homeostasis. Nevertheless, the secretory pathways of these adipokines and their interplays are poorly elucidated. In...
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sg-ntu-dr.10356-944382023-12-29T06:48:22Z Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays Ye, Feng Than, Aung Zhao, Yanying Goh, Kian Hong Chen, Peng School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Biomedical engineering Adipose tissue is a highly active endocrine organ secreting a variety of signaling molecules called adipokines. Leptin and resistin are two adipokines critically involved in metabolic homeostasis. Nevertheless, the secretory pathways of these adipokines and their interplays are poorly elucidated. In this work, we have comparatively studied several key aspects of leptin and resistin secretion from 3T3-L1 adipocytes. It was found that leptin and resistin molecules are compartmentalized into different secretory vesicles. The trafficking of leptin and resistin vesicles, and the secretion of leptin and resistin are oppositely regulated by insulin/glycolytic substrates and cAMP/protein kinase A. Interestingly, these two adipokines adversely influence each other on secretion and vesicle trafficking. Finally, we demonstrated that both leptin and resistin secretion are Ca2+ dependent. Accepted version 2012-02-06T02:56:18Z 2019-12-06T18:56:01Z 2012-02-06T02:56:18Z 2019-12-06T18:56:01Z 2010 2010 Journal Article Ye, F., Than, A., Zhao, Y., Goh, K. H. & Chen, P. (2010). Vesicular storage, vesicle trafficking, and secretion of leptin and resistin: the similarities, differences and interplays. Journal of Endocrinology, 206, 27–36. https://hdl.handle.net/10356/94438 http://hdl.handle.net/10220/7502 10.1677/JOE-10-0090 153339 en Journal of endocrinology © 2010 Society for Endocrinology. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Endocrinology, Society for Endocrinology. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1677/JOE-10-0090 ] 35 p. application/pdf |
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DRNTU::Science::Medicine::Biomedical engineering Ye, Feng Than, Aung Zhao, Yanying Goh, Kian Hong Chen, Peng Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays |
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Adipose tissue is a highly active endocrine organ secreting a variety of signaling molecules called adipokines. Leptin and resistin are two adipokines critically involved in metabolic homeostasis. Nevertheless, the secretory pathways of these adipokines and their interplays are poorly elucidated. In this work, we have comparatively studied several key aspects of leptin and resistin secretion from 3T3-L1 adipocytes. It was found that leptin and resistin molecules are compartmentalized into different secretory vesicles. The trafficking of leptin and resistin vesicles, and the secretion of leptin and resistin are oppositely regulated by insulin/glycolytic substrates and cAMP/protein kinase A. Interestingly, these two adipokines adversely influence each other on secretion and vesicle trafficking. Finally, we demonstrated that both leptin and resistin secretion are Ca2+ dependent. |
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School of Chemical and Biomedical Engineering |
author_facet |
School of Chemical and Biomedical Engineering Ye, Feng Than, Aung Zhao, Yanying Goh, Kian Hong Chen, Peng |
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Article |
author |
Ye, Feng Than, Aung Zhao, Yanying Goh, Kian Hong Chen, Peng |
author_sort |
Ye, Feng |
title |
Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays |
title_short |
Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays |
title_full |
Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays |
title_fullStr |
Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays |
title_full_unstemmed |
Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays |
title_sort |
vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays |
publishDate |
2012 |
url |
https://hdl.handle.net/10356/94438 http://hdl.handle.net/10220/7502 |
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1787136573629792256 |