Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays

Adipose tissue is a highly active endocrine organ secreting a variety of signaling molecules called adipokines. Leptin and resistin are two adipokines critically involved in metabolic homeostasis. Nevertheless, the secretory pathways of these adipokines and their interplays are poorly elucidated. In...

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Main Authors: Ye, Feng, Than, Aung, Zhao, Yanying, Goh, Kian Hong, Chen, Peng
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2012
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Online Access:https://hdl.handle.net/10356/94438
http://hdl.handle.net/10220/7502
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-944382023-12-29T06:48:22Z Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays Ye, Feng Than, Aung Zhao, Yanying Goh, Kian Hong Chen, Peng School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Biomedical engineering Adipose tissue is a highly active endocrine organ secreting a variety of signaling molecules called adipokines. Leptin and resistin are two adipokines critically involved in metabolic homeostasis. Nevertheless, the secretory pathways of these adipokines and their interplays are poorly elucidated. In this work, we have comparatively studied several key aspects of leptin and resistin secretion from 3T3-L1 adipocytes. It was found that leptin and resistin molecules are compartmentalized into different secretory vesicles. The trafficking of leptin and resistin vesicles, and the secretion of leptin and resistin are oppositely regulated by insulin/glycolytic substrates and cAMP/protein kinase A. Interestingly, these two adipokines adversely influence each other on secretion and vesicle trafficking. Finally, we demonstrated that both leptin and resistin secretion are Ca2+ dependent. Accepted version 2012-02-06T02:56:18Z 2019-12-06T18:56:01Z 2012-02-06T02:56:18Z 2019-12-06T18:56:01Z 2010 2010 Journal Article Ye, F., Than, A., Zhao, Y., Goh, K. H. & Chen, P. (2010). Vesicular storage, vesicle trafficking, and secretion of leptin and resistin: the similarities, differences and interplays. Journal of Endocrinology, 206, 27–36. https://hdl.handle.net/10356/94438 http://hdl.handle.net/10220/7502 10.1677/JOE-10-0090 153339 en Journal of endocrinology © 2010 Society for Endocrinology.  This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Endocrinology, Society for Endocrinology.  It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document.  The published version is available at: [DOI: http://dx.doi.org/10.1677/JOE-10-0090 ] 35 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Medicine::Biomedical engineering
spellingShingle DRNTU::Science::Medicine::Biomedical engineering
Ye, Feng
Than, Aung
Zhao, Yanying
Goh, Kian Hong
Chen, Peng
Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays
description Adipose tissue is a highly active endocrine organ secreting a variety of signaling molecules called adipokines. Leptin and resistin are two adipokines critically involved in metabolic homeostasis. Nevertheless, the secretory pathways of these adipokines and their interplays are poorly elucidated. In this work, we have comparatively studied several key aspects of leptin and resistin secretion from 3T3-L1 adipocytes. It was found that leptin and resistin molecules are compartmentalized into different secretory vesicles. The trafficking of leptin and resistin vesicles, and the secretion of leptin and resistin are oppositely regulated by insulin/glycolytic substrates and cAMP/protein kinase A. Interestingly, these two adipokines adversely influence each other on secretion and vesicle trafficking. Finally, we demonstrated that both leptin and resistin secretion are Ca2+ dependent.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Ye, Feng
Than, Aung
Zhao, Yanying
Goh, Kian Hong
Chen, Peng
format Article
author Ye, Feng
Than, Aung
Zhao, Yanying
Goh, Kian Hong
Chen, Peng
author_sort Ye, Feng
title Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays
title_short Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays
title_full Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays
title_fullStr Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays
title_full_unstemmed Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays
title_sort vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays
publishDate 2012
url https://hdl.handle.net/10356/94438
http://hdl.handle.net/10220/7502
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