Involvement of PKC-alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells

• Main Authors: Xue, Renhao, Zhao, Yanying, Chen, Peng
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Medicine::Biomedical engineering
• Online Access: https://hdl.handle.net/10356/94487; http://hdl.handle.net/10220/7524
• Institution: Nanyang Technological University

Phorbol-12-myristate-13-acetate, a stable analog of the important signaling membrane lipid diacylglycerol (DAG), is known to potentiate exocytosis and modulate vesicle fusion kinetics in neurons and endocrine cells. The exact mechanisms underlying the actions of PMA, however, is often not clear, lar...