Surface immobilized cholera toxin B subunit (CTB) facilitates vesicle docking, trafficking and exocytosis

• Main Authors: Soo, Jianchow, Zhang, Jing, He, Qiyuan, Agarwal, Shuchi, Li, Hai, Zhang, Hua, Chen, Peng
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/94544; http://hdl.handle.net/10220/8406
• Institution: Nanyang Technological University

The subunit B of cholera toxin (CTB), which specifically binds with ganglioside GM1 enriched in membrane lipid rafts, is known to interfere with multiple cell functions. However, the specific, stable and spatially defined membrane signaling induced by CTB binding is often difficult to inves...