Brønsted acid catalyzed α-alkylation of aldehydes with diaryl methyl alcohols
A proton does the two jobs: Brønsted acids alone catalyze the α-alkylation of aldehydes with diaryl alcohols. In this type of transformation, the acid-catalysis approach offers a broader substrate scope compared to the previously used enamine catalysis methods. The acid plays two important roles: on...
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| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2012
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| Online Access: | https://hdl.handle.net/10356/94631 http://hdl.handle.net/10220/8118 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | A proton does the two jobs: Brønsted acids alone catalyze the α-alkylation of aldehydes with diaryl alcohols. In this type of transformation, the acid-catalysis approach offers a broader substrate scope compared to the previously used enamine catalysis methods. The acid plays two important roles: one is to mediate the alcohol dehydration for carbocation formation; the other is to accelerate the rate-determining aldehyde enolization. |
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