Cyclotides : a novel class of natural antibiotics
Cyclotides are circular plant proteins that are approximately 30 amino acids long and have high heat and enzymatic stability. Their N- and C- termini are joined together to form a continuous cyclic conformation. The three-dimensional structure is stabilized by three disulphide bonds arranged in a cy...
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| Other Authors: | |
| Format: | Student Research Poster |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/94747 http://hdl.handle.net/10220/9045 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Cyclotides are circular plant proteins that are approximately 30 amino acids long and have high heat and enzymatic stability. Their N- and C- termini are joined together to form a continuous cyclic conformation. The three-dimensional structure is stabilized by three disulphide bonds arranged in a cystine knot. Cyclotides are known to be antimicrobial, hemolytic, immunomodulating and anti-cancer, thus forming the basis of medicinal plants against various diseases. Bacterial drug resistance is a major concern, and there is an urgent need to discover novel antibiotics. In this project, we are looking at the antibacterial function of cyclotides extracted from a locally grown
plant, Clitoria ternatea which belongs to the Fabaceae family. My results show that cyclotides are potent antimicrobial agents and exhibit synergy with conventional antibiotics. [Peer Assessment Review] |
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