Exploring the mechanism of Zanamivir resistance in a neuraminidase mutant : a molecular dynamics study

It is critical to understand the molecular basis of the drug resistance of influenza viruses to efficiently treat this infectious disease. Recently, H1N1 strains of influenza A carrying a mutation of Q136K in neuraminidase were found. The new strain showed a strong Zanamivir neutralization effect. I...

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Bibliographic Details
Main Authors: Han, Nanyu, Liu, Xue-Wei, Mu, Yuguang
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/95313
http://hdl.handle.net/10220/9270
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Institution: Nanyang Technological University
Language: English