Crystallization studies of the murine c-di-GMP sensor protein STING

• Main Authors: Chou, Shan-Ho, Su, Yi-Che, Tu, Zhi-Le, Yang, Chao-Yu, Chin, Ko-Hsin, Chuah, Mary Lay-Cheng, Liang, Zhao-Xun
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/95453; http://hdl.handle.net/10220/9184
• Institution: Nanyang Technological University

The innate immune response is the first defence system against pathogenic microorganisms, and cytosolic detection of pathogen-derived DNA is believed to be one of the major mechanisms of interferon production. Recently, the mammalian ER membrane protein STING (stimulator of IFN genes; also known as...