Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures

• Main Authors: Zhang, Juan, Wang, Lihua, Pan, Dun, Song, Shiping, Boey, Freddy Yin Chiang, Zhang, Hua, Fan, Chunhai
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/95589; http://hdl.handle.net/10220/8604
• Institution: Nanyang Technological University

A novel bioassay strategy is designed to detect small-molecule targets such as cocaine, potassium, and adenosine, based on gold nanoparticles (AuNPs) and engineered DNA aptamers. In this design, an aptamer is engineered to be two pieces of random, coil-like single-stranded DNA, which reassembles int...