Differences in the binding affinities of ErbB family : heterogeneity in the prediction of resistance mutants

• Main Authors: Verma, Chandra S., Pereira, Mariana, Fuentes, Gloria
• Other Authors: Salsbury Jr., Freddie
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/95747; http://hdl.handle.net/10220/18380
• Institution: Nanyang Technological University

The pressure exerted by drugs targeted to a protein in any therapy inevitably leads to the emergence of drug resistance. One major mechanism of resistance involves the mutation of key residues in the target protein. Drugs that competitively replace a natural substrate are often made ineffective by m...