SMAD3 deficiency promotes inflammatory aortic aneurysms in angiotensin II–infused mice via activation of iNOS

• Main Authors: Tan, Eddie H., Tan, Chek Kun, Luo, Baiwen, Huang, Charlotte Liwen, Loo, Say Chye Joachim, Choong, Cleo Swee Neo, Tan, Nguan Soon
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/95753; http://hdl.handle.net/10220/10649
• Institution: Nanyang Technological University

Ninety percent of the patients carrying distinct SMAD3 mutations develop aortic aneurysms and dissections, called aneurysms-osteoarthritis syndrome (AOS). However, the etiology and molecular events downstream of SMAD3 leading to the pathogenesis of aortic aneurysms in these patients still remain elu...